【Abstract】 Objective To investigate the effect of LncRNA UCA1 on the proliferation, migration and invasion of cervical cancer cells via miR-206 / PTP1B axis. Methods qRT-PCR was used to detect the expression of UCA1 and miR-206 in cervical cancer cells. Western blot was used to detect the expression of PTP1B in cervical cancer cells. luciferase reporter gene experiment was used to verify the targeting relationship between UCA1 and miR-206, miR-206 and PTP1B. CCK -8 was used to detect cervical cancer cell viability; flow cytometry was used to detect cervical cancer cell apoptosis. Transwell test was used to detect cervical cancer cell migration and invasion ability. Results Compared with human normal cervical epithelial cells, UCA1 expression was significantly increased in cervical cancer cells (P＜0.01), and miR-206 expression was significantly decreased (P＜0.05). Compared with the si-NC group, the UCA1 expression, cell viability, migration and invasion ability of the si-UCA1 group were significantly reduced (P＜0.01), and the apoptosis rate was significantly increased (P＜0.01). There is a mutual regulation effect between UCA1 and miR-206; compared with miRNC+siNC group, the cell viability, migration and invasion ability of miR-206 + si-NC group are significantly reduced (P＜0.05), and the rate of apoptosis significantly increased (P＜0.01), the anti-miR-206+si-NC group showed opposite changes. Compared with the anti-miR-206 + si-NC group, the cell viability, migration and invasion ability of the anti-miR-206 + si-UCA group were significantly reduced (P＜0.01), and the apoptosis rate was significantly increased (P＜0.01). Compared with miR-NC+si-NC group, the cell viability, migration and invasion ability of anti-miR-206+si-NC group were significantly increased (P＜0.05), and the rate of apoptosis significantly decreased (P＜0.05), miR-NC+si-PTP1B group showed opposite changes. Compared with anti-miR-206+si-NC group, cell viability, migration and invasion ability was significantly reduced (P＜0.05), and the apoptosis rate was significantly increased (P＜0.05). Conclusion LncRNA UCA1 promotes the proliferation, migration and invasion of cervical cancer cells by regulating the miR-206/PTP1B axis.