【Abstract】Objective To investigate the value of EQ5D5L in the evaluation of life quality and psychosocial factors of maintenance hemodialysis (MHD) patients. Methods A questionnaire survey was conducted on 176 patients who received maintenance hemodialysis in the hemodialysis center of West China Hospital of Sichuan University by using European Fivedimensional Health Scale (EQ5D5L). The association with general data, Pittsburgh Sleep Quality Index, General Hospital Anxiety and Depression Scale (HADS), Social Support Rating Scale, and Piper Fatigue Rating Scale was analyzed. Univariate and multivariate analyses were carried out on the correlation between the factors and the influencing factors. Results The EQ5D5L score of MHD patients was (086±012). Pittsburgh sleep quality Index score, HADS score and Piper fatigue scale score were negatively correlated with EQ5D5L (P＜005), while social support score was positively correlated with EQ5D5L (P＜005). Patients with HADS, age, fatigue, and work after dialysis were all the influencing factors of EQ5D5L (P＜005). Conclusion HADS, age, fatigue and unemployment all affect the quality of life of MHD patients. The more serious anxiety, depression, sleep quality and fatigue they had, they had poor the quality of life. If they got the more social support, they would have led the higher quality of life. EQ5D5L is of great value in the assessment of the quality of life and psychosocial factors of MHD patients, and can be popularized and applied in clinical practice to improve the quality of life of MHD patients.