红细胞分布宽度与淋巴细胞比值对结直肠癌的诊断价值
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江苏省卫生计生委科研项目(H2017082)


Evaluation of the diagnostic value of red cell distribution widthtolymphocyte ratio in colorectal cancer
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    【摘要】目的 研究红细胞分布宽度与淋巴细胞比值(RLR)对结直肠癌的诊断价值。方法 选取2012年6月~2020年5月在徐州医科大学附属医院诊治的501例结直肠癌患者(结直肠癌组)、404例结直肠息肉患者(结直肠息肉组)及同期健康体检者424例正常对照者(对照组),检测三组受试者外周血RLR、CEA、CA199水平,比较RLR、CEA、CA199三者对结直肠癌的诊断效率,分析结直肠癌组RLR与CEA、CA199之间的Spearman相关性。结果 结直肠癌组患者外周血RLR水平高于结直肠息肉组和对照组,差异有统计学意义(P<005)。RLR与CEA、CA199成正相关,Spearman相关系数分别为0128、0227(P<005)。通过ROC曲线,RLR、CEA、CA199最佳截断值时对应的灵敏度分别为557%、637%、397%,特异度分别为676%、792%、879%。有远处脏器转移的晚期患者RLR明显高于无脏器转移患者,差异有统计学意义(P<005)。结论 单一检测RLR灵敏度及特异度均较低,RLR联合CEA、CA199检测可提高诊断结直肠癌的灵敏度,有利于结直肠癌的早期诊断与预后判断。

    Abstract:

    【Abstract】Objective To explore the diagnostic value of red cell distribution widthtolymphocyte ratio (RLR) for colorectal cancer, and compare its difference with CEA and CA199 in the diagnosis of colorectal cancer. Methods A total of 501 patients with colorectal cancer(colorectal cancer group), 404 patients with colorectal polyps(colorectal polyp group) and 424 healthy subjects control group were selected from the Affiliated Hospital of Xuzhou Medical University from June 2012 to May 2020. The levels of RLR, CEA and CA199 in peripheral blood of the three groups of subjects were detected and compared with RLR, CEA and CA199 The diagnostic efficiency of the three for colorectal cancer, and the Spearman correlation between RLR and CEA and CA199 in the colorectal cancer group was analyzed. Results The level of RLR in peripheral blood of colorectal cancer was higher than that of colorectal polyp group and normal control, and the difference was statistically significant (P<005). RLR is positively correlated with CEA and CA199, and Spearman's correlation coefficients are 0128 and 0227 (P<005). Through the ROC curve, the sensitivities corresponding to the best cutoff values of RLR, CEA, and CA199 are: 557%, 637%, 397%, and the specificities are 676%, 792%, and 87.9%, respectively. The RLR of patients with distant organ metastasis was significantly higher than that of patients without organ metastasis, and the difference was statistically significant (P<005). ConclusionThe sensitivity and specificity of a single detection of RLR are low. The sensitivity of RLR combined with CEA and CA199 detection in the diagnosis of colorectal cancer is improved, which is conducive to the early diagnosis and prognosis of colorectal cancer.

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  • 在线发布日期: 2021-08-16
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