【Abstract】Objective To explore the application and effect of hospital-community-family closed-loop management mode in elderly patients with diabetic peripheral neuropathy (DPN). Methods 96 elderly patients with DPN treated from June 2017 to June 2019 were enrolled. They were randomly divided into experimental group and control group, 48 cases in each group. The control group was given routine nursing, while experimental group was given hospital-community-family closed-loop management mode. The treatment compliance, blood glucose control, psychological health, peripheral neuropathy and nerve conduction velocity in both groups were observed.Results After intervention, compliance rates to medication, diet, blood glucose measurement and health behaviors in experimental group were 95.83%, 91.67%, 93.75% and 87.50%, which were higher than those in control group (83.33%, 75.0%, 77.08%, 68.75%) (P＜0.05). The fasting blood glucose, 2h postprandial blood glucose and glycosylated hemoglobin in experimental group were lower than those in control group (P＜0.05). The scores of somatization, interpersonal sensitivity, depression, anxiety, hostility, sleep and diet in Symptom check list90 (SCL-90) in experimental group were lower than those in control group (P＜0.05). Michigan Diabetic Neuropathy Score(MDNS) and Toronto Clinical Scoring System(TCSS) score in experimental group were lower than those in control group (P＜0.05). The sensory nerve conduction velocity (SNCV) and motor nerve conduction velocity (MNCV) of median nerve and common peroneal nerve in experimental group were higher than those in control group (P＜0.05). Conclusion The application of hospital-community-family closed-loop management mode in elderly DPN patients can improve self-management efficiency, maintain stable blood glucose, relieve negative emotions and improveDPN.