【Abstract】Objective To explore the relationship between serum fibroblast growth factor 23 (FGF23), Apelin and urine β2-microglobulin (β2-MG) and hypertensive disorder complicating pregnancy (HDCP). Methods 189 HDCP patients (observation group) admitted from January 2018 to December 2019 were included as the research subjects, and another 100 normal pregnant women during the same period were selected as control group. The levels of serum FGF23, Apelin and urine β2-MG were compared. The correlation between the diseaseseverity of HDCP patients and FGF23, Apelin and urine β2-MG was analyzed. The mother-infant outcomes were followed up and recorded in observation group and control group. Laboratory indexes levels were compared among patients with different mother-infant outcomes.Results The levels of FGF23 and urine β2-MG in PE group and GH group were higher than those in control group (P＜0.05), while the level of Apelin was lower than that in control group (P＜0.05). The levels of FGF23 and urine β2-MG in PE group were higher than those in GH group (P＜0.05) while the Apelin level was lower than that inGH group (P＜0.05). The levels of FGF23 and urine β2-MG of severe patients in PE group and GH group were higher than those of mild patients (P＜0.05) while the Apelin level was lower than thatof mild patients (P＜0.05).Spearman correlation analysis showed FGF23 and urinary β2-MG were positively correlated with the diseaseseverity of HDCP (P＜0.05), and were negatively correlated with Apelin (P＜0.05). The incidence rates of postpartum hemorrhage, acute kidney injury and abnormal glucose tolerance in observation group were higher than those in control group (P＜0.05), and the incidence rates of fetal distress and low birth weight infant in observation group were higher than those in control group (P＜0.05). The levels of serum FGF23 and urinary β2-MG of HDCP patients with poor mother-infant outcomes were higher than those of patients with normal pregnancy outcomes (P＜0.05)，while the Apelin level was lower than that of patients with normal pregnancy outcomes (P＜0.05). Conclusion The levels of serum FGF23, Apelin and urinary β2-MG are related to the diseaseseverity of HDCP, and monitoring the levels of the above indicators is helpful to predict pregnancy outcomes.