European Association of Echocardiography (EAE) and American Society of Echocardiography (ASE) released the latest clinical application of ultrasound contrast agents in 2017 and 2018. Chinese translation of "Clinical Applications of Ultrasonic Enhancing Agents (UEA) in Echocardiography 2018 Update" published in Chinese Journal of Ultrasonography, Volume 28, issue 7, July 2019. The introduction of Chinese version will greatly promote the clinical application of ultrasound enhancing agents in echocardiography. In addition, “Expert consensus on clinical application of cardiac ultrasound contrast agents” published in Chinese Journal of medical ultrasound (Electronic Edition), Volume 16, issue 10, October 2019. In consideration of the fact that the clinical application of ultrasound enhancing agents is not widespread in China, and in order to promote and standardize the clinical application of ultrasound enhancing agents, we write this paper. The main points of "2018 ASE guidelines update" and "Expert consensus on clinical application" are as follows.