【Abstract】 Rheumatoid arthritis (RA) is a common systemic autoimmune disease, but its etiology and pathogenesis are still not very clear. Environmental and genetic factors are involved in the pathogenesis of rheumatoid arthritis. In recent years, more and more evidences have confirmed that the dysbiosis of intestinal flora have been associated with rheumatoid arthritis. In this review, we will focus on the association between intestinal microflora and the pathogenesis of RA.