【Abstract】Objective To investigate the clinic effect of glucocorticoid combined with hemoperfusion in treating MODS caused by severe bee sting. Methods 66 patients with MODS caused by severe bee sting admitted to our hospital from June 2014 to March 2016 were selected and divided into observation group and control group, 33 cases in each group. Control group was given regular treatment and HP. Observation group was given glucocorticoid based on control group. Clinic data of the two groups were retrospectively analyzed. The clinical efficacy and safety of glucocorticoid combined with hemoperfusion (HP) in the treatment of multiple organ dysfunction syndrome (MODS) caused by severe bee stings were compared and analyzed. Results No significant difference was detected between the two groups in the mortality rate (P＞0.05). No significant differences were detected in the levels of Scr, BUN, ALT, AST, CK-MB, CRP and Hbrelated biochemical indexes between the two groups before treatment (P＞0.05). The levels of Scr, BUN, ALT, AST, CK-MB, CRP and Hbrelated biochemical indexes were statistically significant different (P＜0.05). No significant difference was detected between the two groups in the incidence of oliguria, uremia and polyuria (P＞0.05). Significant difference was detected between the two groups in the duration of polyuria and the recovery time of renal function (P＜0.05). Conclusion The combination of glucocorticoid and hemoperfusion in the treatment of multiple organ dysfunction syndrome (MODS) caused by severe bee stings is more effective, which is beneficial to the recovery of organ function, shorten the treatment time and improve the patients prognosis.