【Abstract】 Objective To explore the differential diagnosis value of DCEMRI combined with DWI in musculoskeletal system benign and malignant lesions.Methods 80 musculoskeletal tumor patients pathologically confirmed were involved in this study. They were divided into benign group ( n=35) and malignant group ( n=45). All the patients were performed conventional DCEMRI ,DWI examination, respectively. We analyzed the data of patients ADC TIC and compared the diagnostic specificity, sensitivity and accuracy. Results The ADC figure, SEE figure and Slope in malignant group were apparently higher than those in benign group (P＜0.05). The best diagnostic threshold of ADC was 115.43×105m2·s1 in ROC curve. The DER differences in malignant and benign group were without statistical value (P＞005). As for TJC curre, patients in malignant group were mostly Ⅲ type (89.1%), while patients in benign group were mainly Ⅰtype curve(57.7%) ( P＜0.05). The sensitivity, specific degrees and accuracy in DCEMRI were respectively 87.09%, 84.77% and 89.02%. The sensitivity，specific degrees and accuracy in DWI were 78.65%, 85.01% and 81.68%.Disimilarly,the sensitivity，specific degrees and accuracy combined DCE MRI with DWI were respectively 91.33%, 94.22% and 90.18%.Conclusion There is high identification value of DCEMRI and DWI in the examination and diagnosis of musculoskefatal system of benign and malignant lesions. Therefore, combining diagnosis can improve the specificity and accuracy degree of diagnosis.