Abstract:【Abstract】Objective To detect serum pepsinogen (PG) and tumor necrosis factorα (TNFα) in patients with Helicobacter pylori (Hp) related gastric diseases, and to explore the significances of PG and TNFα in the diagnosis of Hprelated gastric diseases. Methods From January 2016 to March 2019, 237 patients with Hprelated gastric diseases treated in our hospital were selected as the study subjects. During the same period, 195 healthy people (CG group) were selected as the control group. The levels of serum PGⅠ, PGⅡ and TNFα were detected by ELISA, and the infection of Hp in each group was also detected, and the diagnostic values of PGⅠ, PG Ⅱ and TNFα in Hprelated gastric diseases were analyzed.Results The levels of serum TNFα, PGⅠ and PGⅡ in Hprelated gastric diseases group were significantly higher than those in CG group (P＜005). The levels of serum PGⅠ and PGⅡ in patients with atrophic gastritis were significantly lower than those in patients with superficial gastritis (P＜005). The levels of serum TNFα and PGⅡ in patients with peptic ulcer were significantly higher than those in patients with superficial gastritis and atrophic gastritis, and the level of PG Ⅰ was higher than that in patients with atrophic gastritis (P＜005). The level of serum PGⅡ in patients with gastric cancer was significantly lower than that of superficial gastritis, atrophic gastritis and peptic ulcer, TNFα level was higher than that of superficial gastritis and atrophic gastritis, PGⅠ level was lower than that of superficial gastritis and peptic ulcer, and PGR level was higher than that of superficial gastritis and peptic ulcer (P＜005). The levels of serum TNFα in patients with superficial gastritis and atrophic gastritis with positive Hp were significantly higher than those in patients with negative Hp (P＜005). The levels of serum PGⅠ in patients with Hppositive atrophic gastritis, peptic ulcer and gastric cancer were significantly higher than those in patients with Hpnegative (P＜005). The level of serum PGⅡ in patients with atrophic gastritis with positive Hp was significantly higher than that in patients with negative Hp (P＜005). The AUCs of TNFα, PGⅠ and PGⅡ in the diagnosis of Hprelated gastric diseases were 0858 (95% CI: 08110905), 0824 (95% CI: 07790869) and 0748 (95% CI: 06890806). The truncation values were 12444, 128648 and 28113, respectively. The specificities were 808%, 653% and 502%, and the sensitivities were 792%, 989% and 943%, respectively. The AUCs of PGⅠ and PGⅡ combined with TNFα respectively in patients with Hprelated gastric diseases were 0924 (95% CI: 08910957) and 0901 (95% CI: 08660936). The specificities were 811% and 785%, and the sensitivitties were 981% and 887%, respectively. ConclusionPGⅠ, PGⅡ and TNFα can be used as a reference index for the diagnosis of gastric diseases associated with Hp, and have important significances for the diagnosis of precancerous lesions and early gastric cancer caused by Hp infection.
