Abstract:【Abstract】Objective To compare the effects of parecoxib sodium combined with oxycodone hydrochloride on postoperative recovery quality and inflammatory response in patients undergoing elective laparoscopic surgery. Methods 86 patients undergoing elective laparoscopic surgery were randomly divided into Parecoxib Sodium group (group P) and normal saline group (group C). At about 30 minutes before the end of surgery, oxycodone hydrochloride (0.1 mg/kg) was injected for all patients. The patients in group P were administered intravenous parecoxib sodium (1.0 mg / kg), while patients in group C were injected with an equal volume of normal saline. The visual analogue scale/score (VAS) was used to evaluate the postoperative pain. The quality of recovery scale (QoR40 scale ) was used to evaluate the postoperative recovery quality. The postoperative inflammatory response and average length of hospitalization were also recorded. Results The level of CRP in group P was significantly lower than that in group C (P<005). The total score of QoR40, and the score of the physical comfort and emotional state in group P were higher than those in group C (P<005). There were no significant difference in general information between the two groups (P>005). There were statistically significant difference in the VAS score between the two groups of patients at 6 and 12 hours after surgery (P<005). The average length of hospitalization in group P were shorter than that in group C, and the difference was statistically significant (P<005). Conclusion Intravenous injection of parecoxib sodium can enhance the analgesic effect of oxycodone hydrochloride, improve the quality of recovery after laparoscopic surgery, and reduce postoperative inflammatory reactions.