【Abstract】Objective To investigate the diagnostic value of MENBI combined with Lugol's solution staining in screening highrisk population of esophageal cancer. Methods From January 2016 to December 2018, 500 patients who were screened in the digestive endoscopy center of our hospital for high-risk esophageal cancer were selected as the research objects. All patients were diagnosed by white light endoscopy, me NBI and me NBI combined with Lugol's liquid pigment endoscopy. 198 patients were screened out with pathological changes, 260 cases in total, and the pathological results after biopsy or hand operation were taken as the gold standard The sensitivity, specificity and accuracy of three methods were analyzed.ResultsThe accuracy of MENBI combined with Lugol's liquid staining endoscopy in the diagnosis of early esophageal cancer was significantly higher than that of white light endoscopy and MENBI (2= 34531, P＜0001,2=11134, P=0001). The sensitivity and specificity of MENBI combined with Lugol's liquid staining endoscopy in the diagnosis of early esophageal cancer were significantly higher than that of white light endoscopy (2=39806, P＜0001,2=14457, P＜0001). MENBI combined with Lugol's solution staining was more sensitive and specific than MENBI in the diagnosis of early esophageal cancer, but there was no significant difference in specificity (2=17843, P＜001, 2=0205, P=0651). Conclusion MENBI combined with Lugol's solution staining endoscopy screening for highrisk groups of esophageal cancer can improve the diagnostic accuracy, specificity and sensitivity of early esophageal cancer.