【Abstract】Objective To explore the prevalence and risk factors of sarcopenia in Tibetan patients with liver cirrhosis. Methods 209 cirrhotic Tibetan patients were recruited prospectively between July, 2017 and Sep, 2018 in our hospital and the related clinical data were recorded. Their crosssectional skeletal muscle areas at the level of the L3 vertebra were measured by computed tomography and sarcopenia was determined by L3 skeletal muscle index. Its risk factors were analyzed. Results The skeletal muscle index in 41 patients without sarcopenia was (4893±686) cm2/m2, and the index in 168 patients with sarcopenia was (3750±720) cm2/m2 (P＜001). Among the 209 cirrhotic Tibetan patients, the prevalence of sarcopenia was 8038%. The prevalence of sarcopenia in male cirrhotic patients was significantly higher in than that in female (9567% vs 2765%, P＜001). Logistic regression model was performed after setting sarcopenia according to the value of skeletal muscle index as the dependent variable, and age, gender, body mass index, albumin, cholesterol, triglyceride, ChildPugh score were deemed as independent variables. We found that lower body mass index, decreased albumin and male gender, were found to be independently associated with increased risk of sarcopenia.ConclusionThis study suggests that sarcopenia might be prevalent in Tibetan patients with liver cirrhosis. Sarcopenia might affect male patients more than female. Lower body mass index, decreased albumin and male gender are risk factors for sarcopenia.