【Abstract】Objective To explore the efficacy of sucralfate suspension combined with omeprazole entericcoated tablets on treatment of raised erosive gastritis (REG). Methods 82 patients with REG admitted to West China Hospital, Sichuan University from May 2016 to May 2019 were selected and randomly divided into observation group and control group, according to the envelope method. Observation group was treated with sucralfate suspension + omeprazole entericcoated tablets, and control group was treated with omeprazole entericcoated tablets. The patients with positive helicobacter pylori (Hp) were treated with antibiotics for eradication of Hp. The clinical efficacy and Hp negative conversion rate were compared between the two groups. Serum pepsinogens (PGI, PGII), gastrin17 (GAS17), inflammatory factors ［interleukin8 (IL8), IL10, tumor necrosis factorα (TNFα)］ and expressions of epidermal growth factor (EGF), basic fibroblast growth factor (bFGF) and antigen Ki67 in gastric mucosal tissues were observed before and after treatment. ResultsThe total effective rate of treatment in observation group was higher than that in control group (P＜005). There was no significant difference in the Hp negative conversion rate between the two groups (P＞005). After 8 weeks of treatment, the levels of serum PGI and GAS17 and PGR in the two groups were higher than those before treatment. The levels in 〖JP2〗observation group were higher than those in control group (P＜005). The levels of serum PGII, IL8, IL10 and TNFα〖JP〗 were lower than those before treatment, and the levels in observation group were lower than those in control group (P＜005). After 8 weeks of treatment, the levels of EGF, bFGF and Ki67 in gastric mucosa in the two groups were lower than those before treatment, and the levels in observation group were lower than those in control group (P＜005). Conclusion Sucralfate suspension combined with omeprazole entericcoated tablets has a good synergistic effect on REG. It can effectively reduce the inflammatory response, promote the recovery of gastric mucosal function, and facilitate the outcome of the disease.