Abstract:【Abstract】Cholangiocarcinoma is the malignancy that originates from the epithelium of the bile duct. The update of the version1. 2020 of the NCCN Guideline in the United States includes: ①The guideline further explained the 8th edition of AJCC staging system.②The guideline further emphasized the need for lymphadenectomy in porta hepatis for patients with intrahepatic cholangiocarcinoma.③Systematic treatment was emphasized in unresectable patients.④Adjuvant treatment was more standardized.⑤It was recommended to carry out MSI/dMMR testing and gene testing for advanced cholangiocarcinoma. The progress of the diagnosis and treatment of cholangiocarcinoma in the updated version of the NCCN guide were interpretated in this paper, and some undiscussed part of the guideline were supplemented.