【Abstract】 Objective To study the abnormal expressions of long noncoding RNA PVT1 (LncRNA PVT1) and micro RNA30d (miR30d) in epithelial ovarian cancer, and explore the relationships between LncRNA PVT1 and miR30d with chemosensitivity and prognosis of patients with epithelial ovarian cancer. Methods 76 patients with epithelial ovarian cancer underwent surgical treatment from February 2012 to January 2014 were selected as the epithelial ovarian cancer group, and 76 patients with benign ovarian tumors in our hospital were selected as the control group. The relative expressions of LncRNA PVT1 and miR30d were detected by qRTPCR. According to the sensitivity to Cisplatin (DDP), Adriamycin (ADM), Cyclophosphamide (CTX), the patients were divided into sensitive group and resistant group, and the expressions of LncRNA PVT1 and miR30d were compared. Pearson method was used to analyze the correlation between the expressions of MV30d and LncRNA PVT1. KaplanMeier was used to analyze the 5year survival of patients with epithelial ovarian cancer. Results Compared with the adjacent tissue group, the expression of miR30d in epithelial ovarian cancer group decreased (P＜0.05), while the expression of LncRNAPVT1 increased (P＜0.05). The expressions of miR30d and LncRNAPVT1 were closely related to FIGO stage and differentiation degree. The expression level of miR30d in DDP and ADM sensitive group was significantly higher than that in drug resistant group, and the expression level of LncRNAPVT1 was significantly lower than that in drug resistant group (P＜0.05). Pearson correlation analysis showed that the expressions of MV30d and LncRNA PVT1 were negatively correlated in epithelial ovarian cancer (P＜0.05). KaplanMeier analysis showed that the 5year overall survival rate and median survival time of the miR30d highexpressed group were significantly higher than those of the lowexpressed group (73.7% VS 33.3%, 2810months VS 2010months, P＜0.05). The 5year overall survival rate and median survival time of LncRNA PVT1 lowexpressed group were much higher than those of highexpressed group (81.5% VS 22.4%, 2710months VS 1810months, P＜0.05). Conclusion In cancer tissues of patients with epithelial ovarian cancer, the expression of miR30d is low and LncRNA PVT1 is high. The expressions of miR30d and LncRNAPVT1 are related to the chemosensitivity and prognosis of epithelial ovarian cancer.