【Abstract】 Objective To explore the etiology of placental hypoplasia and maternal organic vascular disorder in pregnant women with pregnancyinduced hypertension and preeclampsia. Methods From February 2017 to February 2019, 23 pregnant women with gestational hypertension (GH group), 23 pregnant women with preeclampsia (PE group) and 26 normal pregnant women (control group) were selected as the study objects. The serum derivatives of active oxygen metabolites (d-ROM) and serum biological antioxidants (BAP) were analyzed by free radical analysis system 4. The serum concentrations of soluble FMS like tyrosine kinase-1 (SFLT-1) and placental growth factor (PlGF) were determined by ELISA. The brachial artery flow mediated vasodilation (FMD) and carotid intima-media thickness (IMT) were measured by Doppler ultrasound. Immunohistochemical analysis of 8-hydroxy 2-′-deoxyguanosine (8-OHdG), redox factor-1 (Ref-1), hypoxia inducible factor 1-α (HIF 1-α). Results The systolic and diastolic blood pressure of GH group and PE group increased significantly during pregnancy. The systolic blood pressure of GH group and PE group increased significantly one year after delivery, and GH group was higher than PE group. The diastolic blood pressure of GH group increased significantly one year after delivery (P＜0.05). The concentrations of D ROM and BaP in GH group and PE group were significantly higher than those in PE group (P＜0.05). Compared with GH group and control group, the maternal serum SFLT-1 concentration and the ratio of SFLT-1 / p1gf in PE group increased significantly(P＜0.05). The serum PlGF concentration of GH group and PE group was significantly lower than that of GH group (P＜0.05). The proportion of HIF 1-α, 8-OHdG positive nuclei in GH group and PE group was significantly higher than that in GH group. Compared with PE group and control group, the proportion of ref-1 positive nuclei in GH group increased significantly (P＜0.05). The FMD and IMT of GH group and PE group were significantly lower and higher than those of PE group(P＜0.05). Conclusion The changes of placental hypoxia and DNA oxidative damage were serious in PE patients, accompanied by the increase of anti angiogenic factors, and the disorder of maternal organic blood vessels in GH patients was more serious than that in PE patients.