【Abstract】 Objective To analyze the clinical curative effect of milrinone combined with digitalis in the treatment of uremic hemodialysis with heart failure. Methods 67 patients with uremia complicated with heart failure underwent hemodialysis in the hospital from January 2014 to April 2018 were selected as subjects. They were divided into the observation group (n=30) and the control group (n=37) by the random number table method. The control group was treated with digitalis, while the observation group was treated with milrinone on the basis of the treatment for control group. The clinical curative effect, blood gas analysis, ultrasonic cardiac parameters and myocardial markers were compared between the two groups. The 28day mortality rate, readmission rate and incidence of adverse reactions were statistically analyzed. Results There was no significant difference in the grade of curative effect, total effective rate, 28day mortality or 28 day readmission rate between the two groups (P＞0.05). Heart rate (HR), partial pressure of carbon dioxide (PaCO2) and brain natriuretic peptide (BNP) decreased significantly, while partial pressure of oxygen (PaO2), stroke volume (SV), cardiac output (CO), cardiac index (CI), left ventricular ejection fraction (LVEF), the ratio of the maximum early diastolic flow velocity to the maximum late diastolic flow velocity (E/A) and hydrogen sulfide (H2S) increased significantly after treatment. The HR, PaCO2 and BNP in the observation group were significantly lower than those in the control group. PaO2, SV, CO, CI, LVEF, E/A and H2S were significantly higher than those in the control group (P＜0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P＞0.05). Conclusion Milrinone combined with digitalis is effective and safe in the treatment of uremic hemodialysis with heart failure. The improvement of hemodynamics and cardiac function is better than that of digitalis alone.