【Abstract】 Objective To explore the clinical characteristics of new cerebral infarction in patients with asymptomatic cerebral infarction (SBI) and the influence of related factors. Methods From January 2018 to June 2018, 214 patients with new acute cerebral infarction (ACI) who were hospitalized in the Department of Neurology, Affiliated Hospital of Qingdao University were divided into two groups according to whether there was SBI focus in brain MRI (object n=101) and non SBI (object n=113). The distribution characteristics of the subtypes of toast in the two groups were observed, and the related risk factors and clinical manifestations were analyzed. 87 healthy controls (healthy control group) in the same period were collected for comparison. The levels of C-reactive protein (CRP), platelet lymphocyte ratio (PLR) and neuron specific enolase (NSE) were compared among the three groups. Results There was no significant difference in the distribution of TOAST type between the SBI group and the nonSBI group, and the proportion of large atherosclerotic type (LAA) was largest in both groups. The SBI group was more serious than the nonSBI group. Cerebral infarction patients with vascular white matter lesions or diabetes were easy to be combined with SBI. New cerebral infarction patients with SBI with diabetes or vascular white matter lesion were more serious. CRP, PLR and NSE were all increased in cerebral infarction, and SBI was higher than nonSBI. Conclusion The new cerebral infarction with SBI is more serious. We should pay more attention to the detection of SBI, strengthen the prevention and treatment of cerebrovascular disease for SBI with diabetes and vascular white matter disease. Monitoring CRP, PLR and NSE may find the cases of SBI in time, and reduce the severity of the new cerebral infarction of SBI.