引用本文:[点击复制]
[点击复制]
【打印本页】 【在线阅读全文】【下载PDF全文】 查看/发表评论下载PDF阅读器关闭

←前一篇|后一篇→

过刊浏览    高级检索

本文已被:浏览 110次   下载 28 本文二维码信息
码上扫一扫!
中性粒细胞及血小板与淋巴细胞比值与退行性钙化性主动脉瓣狭窄的相关性分析
颜维剑,柳德斌,朱一林,岳晓通,陶振泽,李俊玮,李娜娜
0
(兰州大学第二医院心脏外科)
摘要:
【摘要】目的 分析中性粒细胞淋巴细胞比值(NLR)和血小板淋巴细胞比值(PLR)与退行性钙化性主动脉狭窄(DCAS)严重程度的关系,并探讨NLR和PLR对DCAS的相关性。方法 回顾性统计2012年1月~2018年12月就诊于我院的经胸超声心动图明确诊断的64例DCAS患者,根据经主动脉平均跨瓣压差大小分为轻至中度DCAS组31例(平均跨瓣压差<40mmHg),重度DCAS组33例(平均跨瓣压差≥40mmHg),并选择同时期就诊的36例健康体检者作为观察组。收集患者的临床资料、超声及实验室检查,计算NLR和PLR,应用受试者工作特征曲线(ROC)评价NLR和PLR在辅助诊断DCAS患者中的价值。结果 与观察组和轻至中度DCAS组相比,重度DCAS组NLR显著增高(P<0.001);重度DCAS组PLR也明显高于观察组和轻至中度DCAS组(P<0.001)。NLR和PLR与经主动脉平均跨瓣压差呈正相关(r=0.493,P<0.001;r=0.301,P=0.016)。当取截断值为4时,NLR辅助诊断DCAS的敏感度为89%,特异度为78%(ACU=0.880,95%CI:0.812~0.947,P<0.001);当取截断值为140时,PLR诊断DCAS的敏感度为79%,特异度为66%(AUC=0801,95%CI:0.711~0.892,P<0.001)。结论 NLR和PLR与DCAS严重程度有关,并且NLR和PLR可能作为一种辅助诊断DCAS的血清炎症提示指标。
关键词:  中性粒细胞-淋巴细胞比值  血小板-淋巴细胞比值  退行性钙化性主动脉瓣狭窄  血清  炎症  辅助诊断
DOI:
基金项目:甘肃省自然科学基金(1506RJZA256);兰州市人才创新创业项目(2017-RC-63);兰州大学第二医院“萃英科技创新”计划项目(CY2017-BJ01)
The corrlation analysis of neutrophil/lymphocyte ratio and platelet lymphocyte ratio with the degenerative calcific aortic stenosis
YAN Weijian,LIU Debin,ZHU Yilin,YUE Xiaotong,TAO Zhenze,LI Junwei,LI Nana
(Department of Cardiac Surgery, Lanzhou University Second Hospital)
Abstract:
【Abstract】 Objective Neutrophil/lymphocyte ratio (NLR) and platelet lymphocyte ratio (PLR) are two emerging serum inflammatory markers, which have been extensively studied in the cardiovascular diseases in recent years. The purpose of this study was to explore the relationship between NLR and PLR and DCAS, and study the assistant diagnostic value of NLR and PLR in DCAS. Methods This study retrospectively reviewed 64 patients with DCAS diagnosed by transthoracic echocardiography in the hospital from January 2012 to December 2018. According to the transaortic mean pressure gradient, 31 patients were classified into the mild to moderate AS group (transaortic mean pressure gradient<40mmHg), and 33 patients were classified into the severe AS group (transaortic mean pressure gradient≥40mmHg), and 36 healthy people visited the hospital at the same period were selected as observation group. The clinical data, ultrasound and laboratory tests of patients were collected. NLR and PLR were calculated. The value of NLR and PLR in DCAS patients was evaluated by receive operating characteristic (ROC). Results Compared with the observation group and mild to moderate DCAS group, the NLR of severe DCAS group was significantly high (4.40±1.68 vs3.36±1.08 vs 2.08±0.75,P<0.001). The PLR of severe DCAS group was also significantly higher than that of control group and mild to moderate DCAS group (191.69±58.00 vs165.41±4.93 vs123.72±46.17,P<0.001). NLR and PLR were positively correlated with transaortic mean pressure gradient (r=0.493, P<0.001; r=0.301, P<0.016). When using a cutoff point of 4, NLR diagnoses the DCAS with a sensitivity of 89% and a specificity of 78% (ACU=0.880, 95%CI:0.812-0.947, P<0.001). When using a cutoff point of 140, the PLR diagnoses the DCAS with a sensitivity of 79% and a specificity of 66% (AUC=0.801, 95%CI: 0.711-0.892, P<0.001). Conclusion NLR and PLR are related to the severity of DCAS, and NLR and PLR can be used as serum inflammatory markers to assist the diagnosis of DCAS.
Key words:  Neutrophil/lymphocyte ratio  Platelet lymphocyte ratio  Degenerative calcific aortic stenosis  Serum inflammatior  Auxiliang diagnosis

用微信扫一扫

用微信扫一扫