血清补体C3、C4、C1q水平与SLE病情活动程度的关系探讨
DOI:
作者:
作者单位:

作者简介:

通讯作者:

基金项目:

陕西省社会发展领域项目(2017SF156)


Relationship between serum complement C3, C4, C1q and the degree of disease activity in systemic lupus erythematosus
Author:
Affiliation:

Fund Project:

  • 摘要
  • |
  • 图/表
  • |
  • 访问统计
  • |
  • 参考文献
  • |
  • 相似文献
  • |
  • 引证文献
  • |
  • 资源附件
    摘要:

    【摘要】 目的 探讨人体血清补体C3、C4、C1q水平与系统性红斑狼疮(SLE)病情活动程度之间的关系。方法 将2017年3月~2018年4月于西安交通大学第二附属医院住院的63例SLE患者按照美国风湿病学会1997年推荐的SLE分类标准分为皮损组10例、初诊组20例、未缓解组33例,另选择45例健康体检者为正常对照组。比较各组血清补体C3、C4、C1q水平,并分析血清补体C3、C4、C1q水平与SLE活动程度之间的关系。结果 皮损组、初诊组和未缓解组SLE患者血清补体C3、C4水平均明显低于正常对照组(P<0.05);而初诊组和未缓解组SLE患者的血清补体C1q水平高于正常对照组(P<0.05);皮损组SLE患者的血清补体C1q水平和正常对照组比较差异无统计学意义(P>0.05);皮损组SLE患者血清C1q水平与正常对照组比较差异无统计学意义(P>0.05)。结论 血清补体C3、C4、C1q水平可在一定程度上判断SLE病情活动程度,定期检测补体C3、C4、C1q的水平并监测其变化程度是判断SLE情活动程度的重要指标。

    Abstract:

    【Abstract】 Objective To investigate the relationship between the level of complement C3, C4, C1q and the severity of systemic lupus erythematosus (SLE) in patients with systemic lupus erythematosus (SLE). Methods From March 2017 to April 2018, 63 patients with SLE in the Department of Dermatology, Department of traditional Chinese Medicine, Department of Nephrology, and Department of Hematology of Xi'an Jiaotong University were divided into skin lesionsgroup (n=10) according to the SLE classification criteria recommended by the American Rheumatology Society in 1997. The levels of serum complement C3, C4 and C1q in newly diagnosed group (n=20), nonremission group (n=33) and healthy control group (n=45) were compared. The relationship between serum complement C3, C4 and C1q level and the active degree of systemic lupus erythematosus was analyzed. Results The levels of serum complement C3 and C4 in SLE patients were significantly lower than those in the normal control group (P<0.05). The level of serum complement C1q in SLE patients was higher than that of the normal control group (P<0.05). Conclusion The level of serum complement C3, C4 and C1q can be used to judge the degree of disease activity of systemic lupus erythematosus to some extent, and the level and variation of complement C 3, C4 and C 1q is an important indicator for the judgment of systemic lupus erythematosus of the degree of disease activity.

    参考文献
    相似文献
    引证文献
引用本文
分享
文章指标
  • 点击次数:
  • 下载次数:
历史
  • 收稿日期:
  • 最后修改日期:
  • 录用日期:
  • 在线发布日期: 2019-11-13
您是第位访问者
版权所有:《西部医学》编辑部     蜀ICP备18038379号-4
地址:四川省成都市武侯区小天竺街75号财富国际18F-1号    邮政编码:610041
电话:028-85570072/85588403    E-mail:xbyxqk@163.com
技术支持:北京勤云科技发展有限公司