血液流变学及凝血指标对妊娠期高血压患者围产结局的影响
DOI:
作者:
作者单位:

作者简介:

通讯作者:

基金项目:

四川省卫计委科研课题(17PJ412)


Effects of hemorheology and coagulation parameters on perinatal outcomes in patients with hypertensive disorder complicating pregnancy
Author:
Affiliation:

Fund Project:

  • 摘要
  • |
  • 图/表
  • |
  • 访问统计
  • |
  • 参考文献
  • |
  • 相似文献
  • |
  • 引证文献
  • |
  • 资源附件
    摘要:

    【摘要】目的 探讨血液流变学及凝血指标对妊娠期高血压患者围产结局的影响。方法 选择2017年2月~〖JP〗2019年1月我院收治妊娠期高血压患者136例为观察组,选择同期入院的正常妊娠妇女136例作为对照组。比较两组孕晚期血液流变学及凝血功能指标变化。比较观察组不同凝血功能指标异常项数者并发症及围产结局发生情况。结果 与对照组比较,观察组孕晚期PT、aPTT、TT显著降低(P<005),Fbg显著升高(P<005);全血高低切黏度、血浆黏度、高低切还原黏度、红细胞压积、红细胞变形指数、红细胞电泳时间、纤维蛋白原显著升高(P<005)。观察组凝血功能指标异常≥3项者的肾功能、肝功能异常及视网膜病变发生率与凝血功能指标异常1~2项者比较显著升高(P<005);新生儿体重、1分钟Apgar评分与凝血功能指标异常1~2项者比较显著降低(P<005),围生儿死亡、剖宫产发生率与凝血功能指标异常1~2项者比较显著升高(P<005)。结论 妊娠期高血压患者妊娠晚期血液流变学及凝血功能指标显著异常,且妊娠期高血压并发症及不良围产结局的发生情况与凝血功能指标异常程度相关。

    Abstract:

    【Abstract】Objective To investigate the effects of hemorheology and coagulation parameters on perinatal outcomes in patients with hypertensive disorder complicating pregnancy. Methods 136 patients with hypertensive disorder complicating pregnancy in our hospital from February 2017 to January 2019 were selected as subjects. Another 136 normal pregnant women admitted to the hospital were selected as the control group. The changes of blood rheology and coagulation function indexes in the third trimester were compared between the two groups. The complications and perinatal outcomes of patients with abnormal hypercoagulability index in patients with hypertensive disorder complicating pregnancy were observed.Results Compared with the normal pregnancy group, PT, aPTT, and TT in the third trimester of pregnancy were significantly lower (P<005), and Fbg was significantly increased (P<005). Whole blood high and low cut viscosity, plasma viscosity, high and low cut reduction viscosity Hematocrit, erythrocyte deformation index, erythrocyte electrophoresis time, and fibrinogen were significantly increased (P<005). In patients with hypertensive disorder complicating pregnancy, the abnormal renal function, abnormal liver function and retinopathy of patients with abnormal coagulation function index ≥3 were significantly higher than those with abnormal blood coagulation index 1~2 (P<005). The neonatal weight, the 1minute Apgar score of patients with abnormal coagulation function index ≥ 3 were significantly lower than those with abnormal blood coagulation index 1~2 (P<005). The incidence of perinatal death, cesarean section of patients with abnormal coagulation function index ≥3 were significantly higher than those with abnormal blood coagulation index 1~2 (P<005).Conclusion The blood rheology and coagulation function indexes of patients with hypertensive disorder complicating pregnancy were significantly abnormal, and the complications of gestational hypertension and the occurrence of adverse perinatal outcome were significantly correlated with the abnormal degree of coagulation function.

    参考文献
    相似文献
    引证文献
引用本文
分享
文章指标
  • 点击次数:
  • 下载次数:
历史
  • 收稿日期:
  • 最后修改日期:
  • 录用日期:
  • 在线发布日期: 2019-11-13
您是第位访问者
版权所有:《西部医学》编辑部     蜀ICP备18038379号-4
地址:四川省成都市武侯区小天竺街75号财富国际18F-1号    邮政编码:610041
电话:028-85570072/85588403    E-mail:xbyxqk@163.com
技术支持:北京勤云科技发展有限公司