【Abstract】Objective To determine the risk and associated factors of obstructive sleep apnea (OSA) in different stages of chronic kidney disease (CKD) patients using sleep respiration questionnaire. Methods 189 CKD patients went to West China Hospital for followup and completed sleep respiration questionnaire (STOPBang Questionnaire) were enroll in this observational study. The participants were divided into three groups (CKD 12 stages (n=96), CKD 34 stages (n=59) and end stage renal disease (n=34) according to estimated glomerular filtration rate. SPSS220 software was utilized to evaluate the correlation between CKD and OSA. Results 111 patients were regarded as having positive symptoms for OSA, while the rest patients (n=78) were not. In CKD 12 stages, 44 patients (458%) had high risk for OSA. 41 patients (695%) and 26 patients (765%) had high risk for OSA in CKD 34 stages and end stage renal disease (ESRD), respectively. The proportions of high risk for OSA in CKD 34 and ESRD were both significantly higher than that in CKD 12 stages (P=0004, P=0002). Binary logistic regression illustrated that gender, age, different CKD stages and BMI were important factors that were associated with OSA in CKD patients (P＜005). Conclusion CKD patients have higher risk for OSA. The risk of OSA increases as eGFR declines. In advanced CKD patients, the proportion of high risk OSA is enhanced significantly. It is necessary to routinely screen OSA in key population.