【Abstract】Objective To study the effects of ginkgetin on the expression level of hypoxiainducible factor1α and airway remodeling in asthmatic rats. Methods 40 SD rats were selected and randomly divided into control group, model group, highdose ginkgetin treatment group (2 mg/d) and lowdose ginkgetin treatment group D (05 mg/d). The model group, highdose ginkgetin treatment group and lowdose ginkgetin treatment group D were given sensitizers of egg albumin (OVA) to construct rat asthma model. After the construction of asthma model, control group was stimulated with normal saline, and the other three groups were stimulated with inhaled egg albumin, and ginkgetin treatment groups were intraperitoneally injected with the corresponding dose of ginkgetin solution at 30 min before stimulation. After 3 w of asthma stimulation, the pathological changes of lung tissues were observed by HE staining, and bronchial wall thickness and smooth muscle thickness were measured. Immunohistochemical staining was used to detect the tissue contents of HIF1α and VEGF in lung tissue sections. Western blot was used to detect the protein expression levels of HIF1α and VEGF in rat lung tissues. Results The airway epithelium in control group was intact and had no obvious changes, and the airway wall and smooth muscle in model group and treatment groups were obviously thickened with mucosa shedding in the epithelium, and the pathological improvement in highdose treatment group was significantly better than that in lowdose treatment group and model group. The analysis of bronchial wall and smooth muscle thickening showed that compared with control group, the bronchial wall and smooth muscle in the other three groups were significantly thickened (P＜005), but the degree of thickening in highdose treatment group was significantly smaller than that in lowdose treatment group and model group. The expression result of HIF1α and VEGF in the tissue samples by western blot showed that the expression levels of HIF1α and VEGF in model group and treatment groups were significantly increased (P＜005), and the increase amount in highdose treatment group was significantly lower than that in lowdose treatment group and model group (P＜005). Conclusion Highdose ginkgetin can inhibit the expression of HIF1α and VEGF in lung tissue of asthmatic rats, affect the proliferation of tissue smooth muscle and thickening of bronchial wall, and interfere with airway remodeling.