Abstract:【Abstract】 Objective Enhanced Recovery After Surgery (ERAS) has been applied to perioperative management of a variety of clinical tumors. The purpose of this study was to observe the effects of ERAS protocol in patients with gastric cancer. Methods The clinical and pathological data of patients with gastric cancer treated from January 2012 to October 2016 were retrospectively analyzed. Patients were divided into ERAS group (GCERAS group) and control group (GC). Propensity score matching is used to adjust age, gender, number of comorbidities, body mass index, tumor stage, distal and total gastrectomy. Patients clinical, pathological characteristics, postoperative complications, postoperative recovery between the two groups were compared. Results 95 patients were included in this study, 20 patients in the GCERAS group and 40 patients in the GC group were matched. Nasogastric tube placement rate (35% vs. 100%, P<0.001) in the GCERAS group were lower than those in the GC group, Fasting time (P<0.001) and hospital stay was shorter (85 vs. 108 days, P=001) in GCERAS group. There were similar complications between the two groups and a 30day readmission rate. Conclusion The implementation of GCERAS significantly promoted postoperative recovery in patients with gastric cancer. This conclusion requires further prospective studies.