【Abstract】 Objective To investigate the regularity and characteristics of adverse drug reactions by SAdemetionine (SAM ) and provide reference for clinical rational drug use. Methods The report of adverse drug reactions by SAM in PubMed, Elsevier, CNKI, weipu and wanfang database from establishing to 2017 were investigated. The age, gender, dosage and time of adverse reactions occurring were analyzed. Results The majority of adverse drug reactions by SAM were in the young, middleaged, and the male, rather than the old. The adverse drug reactions occurred in multiple systems, especially in the cardiovascular system, the skin and respiratory system. The account of standard case was more than the serious. Mass of them had not been documented. The span of occurring time was wide. Conclusion The ADR caused by SAM are widely distributed in young and middleaged men, although the severity of ADR are generally common. The proportion of new ADR is large. It can occur at any time in the course of medication. It should pay more attention to its occurrence characteristics, to ensure the drug use safety.