Abstract:【Abstract】 Objective To observe the efficacy of lowdose aspirin on earlyonset preeclampsia and its effects on maternalinfant outcomes. Methods 94 patients with earlyonset preeclampsia admitted to our hospital from January 2016 to January 2018 were selected and randomly divided into control group (conventional treatment group) and observation group (aspirin anticoagulation group) according to the order of admission, with 47 cases in each group. The two groups were given routine treatment, and observation group was given lowdose aspirin on this basis. The total clinical effective rate at the end of treatment, coagulation function indicators[plasma prothrombin time (PT), activated partial thromboplastin time (APTT), thrombin time (TT), fibrinogen (Fib)], incidence rates of adverse pregnancy outcomes (abnormal renal and liver function, eclampsia, premature delivery, cesarean section, postpartum hemorrhage), perinatal outcomes[neonatal body weight, 1 min neonatal score (Apgar)]and platelets count abnormalities and occurrence of gastrointestinal symptoms during treatment were observed and recorded. Results At the end of treatment, the total effective rate of treatment in observation group was significantly higher than that in control group (P<0.05). The PT, APTT and TT in observation group were significantly longer than those in control group (P<0.05), and the serum Fbg level was significantly lower (P<0.05). There was no significant difference in the cesarean section rate and postpartum hemorrhage rate between the two groups (P>0.05). The incidence rates of liver function damage, renal function damage, eclampsia and preterm birth in observation group were lower than those in control group (all P<0.05). The neonatal body weight and 1min Apgar scores in observation group were higher than those in control group (P<0.05). There were no abnormal platelets count or obvious gastrointestinal symptoms during treatment. Conclusions Lowdose aspirin is safe and effective for the treatment of earlyonset preeclampsia, and it can protect liver and kidney function, reduce complications and improve maternalinfant outcomes.