Abstract:【Abstract】 Objective To investigate the association between the level of adrenaline, the single nucleotide polymorphisms (SNPS) of alpha 2adrenal receptor, and cancerrelated fatigue (CRF) on breast cancer patients in the different treatment periods. Methods 240 patients diagnosed as breast cancer hospitalized from February 2016 to March 2018 in a tumor hospital and two affiliated hospitals of a medical college were divided into operation group, chemotherapy group and radiotherapy group, 80 cases in each group. The CRF of the patients was evaluated and peripheral venous blood was extracted in three different stages. The concentration of adrenaline was measured with ELISA. The genotype was detected by PCR RELP. The association between alpha 2A adrenoceptor single nucleotide polymorphism and cancer fatigue was analyzed with SPSS20_0 statistical software.Results In the different treatment periods, fatigue levels were positively correlated with the level of adrenaline in the blood (P＜0.05). The level of adrenaline in the blood was not the same among patients suffering from the same level of fatigue in different periods of treatment. The adrenaline level of patients with severe fatigue was significantly higher in operation than that in period of radiotherapy (t=237, P＜0.05). The adrenaline level of patients with moderate fatigue was significantly higher in operation than that in period of chemotherapy (t=231, P＜0.01) and radiotherapy (t=604, P＜0.05). The adrenaline level of patients with mild fatigue showed no statistical significance in three different treatment periods (P＞0.05). The distribution of genotypic frequencies of SNPS sites didn't deviate from HardyWeinberg equilibrium in both case group and control group (P＞0.05). The distribution of genotypic at α2AAR1296 site showed no statistical significance between case group and control group (2=1161, P＞0.05). Conclusion CRF is positively correlated with the level of adrenaline in the blood. The polymorphism of α2AAR1296 site may be not associated with CRF.
