【Abstract】 Objective To explore the expression of the circular RNA (circRNA) hsa_circ_0011021 in cervical cancer tissues and cell lines, and study the effect of hsa_circ_0011021 knockdown on the proliferation, migration and invasion of cervical cancer cells. Methods The expression levels of hsa_circ_0011021 in cervical cancer tissues and cervical cancer cell lines (Hela and SiHa) were determined by quantitative realtime PCR (qRTPCR). The effect of hsa_circ_0011021 on the viability and proliferation of cervical cancer cells, CCK8 and colony formation assays were performed in Hela cells were observed. Transwell migration assay and wound scratch assay were carried out to evaluate the effect of hsa_circ_0011021 on the migration and invasion ability of Hela cells.Results The expression level of hsa_circ_0011021 in cervical cancer tissues and Hela and SiHa cells was higher than that in adjacent normal tissues and human immortal keratinocyte line (HaCaT). Knockdown of hsa_circ_0011021 obviously inhibited the proliferation, migration and invasion of Hela cells. Conclusion Knockdown of hsa_circ_0011021 remarkably suppresses the proliferation, migration and invasion of cervical cancer cells.