In recent years, biological agents are widely used in the treatment of rheumatoid arthritis, and provide as a new powerful weapon for the great improvement of the prognosis and disease progression. However, treatment with biological agents increase the risk of infection couldn't be ignored, and became a hot issue in rheumatism field. The incidence of infection in different types of biological agents is not the same, so clinicians should fully assess the patient's condition and the risk of infection, rational use of biological agents to avoid the occurrence of severe infection.