Objective To explore the effects of two different lente glucocorticoids of methylprednisolone and prednisone on postoperative hemorrhage and recovery of the nasal mucosal function in chronic rhinosinusitis with nasal polyp (CRSwNP) after nasal endoscopic surgery (ESS). Methods The clinical data of each 38 patients with CRSwNP treated with methylprednisolone (observation group) or prednisone (control group) in our hospital after ESS surgery were retrospectively analyzed. The nasal mucosal function (mucociliary transport rate, mucociliary clearance speed) and remodeling of nasal mucosa ［tissue transforming growth factorβ-1(TGFβ-1), vascular endothelial growth factor (VEGF)］were compared between the two groups before operation and at 8 weeks after operation, and the nasal mucosal epithelialization time and postoperative hemorrhage were recorded in the two groups. Results At 8 weeks after operation, the mucociliary transport rate and mucociliary clearance speed in the two groups were significantly higher than those before operation (P＜0.05). The levels of TGFβ1 and VEGF in nasal polyps tissues were lower than those before operation (P＜0.05), and the changes in observation group were greater than those in control group (P＜0.05). The postoperative epithelialization time of nasal mucosa and the incidence rate of bleeding events were lower in observation group than those in control group (P＜0.05). Conclusion Methylprednisolone and prednisone both can improve the nasal mucosal function of patients with CRSwNP after ESS, but methylprednisolone can effectively reduce the remodeling of the operative cavity, and can also promote the repair of nasal mucosa, and reduce postoperative bleeding events, therefore it is more beneficial to promote the recovery of nasal mucosal function.