Objective To study the curative efficacy of minimally invasive extraction in treatment of mandibular impacted wisdom tooth and its effects on serum anti gingival leaf bacteria antibody (PgIgG), tumor necrosis factorα(TNFα) and interleukin6 (IL-6) levels. Methods 93 patients of mandibular impacted wisdom tooth received therapy from November 2015 to November 2017 in Shangluo Central hospital were selected as research objects. According to random number table，those patients were divided into the observation group and the control group. The observation group was treated with minimally invasive extraction, while the control group was treated with hammer chop and split crown. The operation conditions, serum antiPgIgG, TNFa, IL-6, visual analogue score (VAS), alveolar bone density and complications were compared between the two groups. Results The operative time in the observation group was significantly shorter than those in the control group, and the intraoperative blood loss was significantly less than those in the control group(P＜0.05). After operation, the serum antiPgIgG, TNFa, IL6 in the two groups were significantly higher than those before operation(P＜0.05), but the serum antiPgIgG, TNFa, IL-6 in the observation group were significantly lower than those in the control group(P＜0.05). The VAS scores in the observation group were significantly lower than those in the control group at after operation1d, 3d and 7d(P＜0.05). The alveolar bone density in the observation group was significantly higher than those in the control group at after operation7d and 30d(P＜0.05). The total incidence of root fracture, abutment loosening, postoperative restriction of mouth opening, cheek swollen, infected and alveolalgia in the observation group was 12.77%, which was significantly lower than those in the control group 30.43% (P＜0.05). Conclusion Minimally invasive extraction is well for mandibular impacted wisdom tooth. The serum anti PgIgG, TNFα and IL-6 were low after operation, and the wound was small. It's helpful to reduce postoperative complications, promote postoperative recovery, and has high clinical application value.