Objective To study application of artificial femoral head replacement in elderly patients with intertrochanteric fracture and its influence on hip joint function. Methods 80 elderly patients of intertrochanteric fracture received therapy from June 2014 to June 2015 in our hospital were selected as research objects. According to random number table, they were divided into the Observation group (n=40) and the control group (n=40). The control group was treated with PFNA internal fixation, while the Observation group was treated with artificial femoral head replacement. The operation time, intraoperative blood loss, bed rest time, hospitalization time, Visual Analogue Scale/Score(VAS), Hip function score (Harris), Nerve growth factor (NGF) and interleukin-6 (IL-6), Osteosin (Sclerostin), type I collagen C terminal peptide (CTX) and osteoprotegerin (OPG), adverse reaction rate, treatment effect in two groups were compared. Results The excellent and good rate of treatment was significantly higher than that of the control group（P＜0.05）. The operation time, intraoperative blood loss, bed rest time and hospital stay in the observation group were significantly lower than that of the control group. The VAS score was significantly lower than that of the control group（P＜0.05）. The Harris score of the observation group was significantly higher than that of the control group（P＜0.05）. There was no significant difference in the level of IL6 between the two groups（P＞0.05）. The level of NGF was significantly higher than that of the control group（P＜0.05）. The level of Sclerostin was significantly higher than that of the control group（P＜0.05）. The level of CTX,OPG was significantly lower than the control group （P＜0.05）. The incidence of adverse reactions was significantly lower than that of the control group（P＜0.05）.Conclusion Artificial femoral head replacement can quickly restore the patient's hip function. It can effectively improve the level of serum Sclerostin, CTX, OPG and NGF, reduce complications, relieve pain and promote early limb exercise.