Objective To investigate the nucleus pulposus extraction combined with interspinous dynamic stabilization & internal fixation system in the treatment of lumbar disc herniation. Methods 42 patients with lumbar disc herniation admitted in our hospital between January 2016 and January 2018 were selected to be treated with nucleus pulposus removal combined with Wallis interspinous dynamic stabilization system. Oswestry dysfunction index (ODI) questionnaire, JOA back pain evaluation criteria and visual analogue scale (VAS) were compared in 1 month, 6 months, and 12 months before and after surgery. The range of motion (ROM) and intervertebral disc height (DH) of the lesion stage and adjacent stage were measured by X-ray examination in 1 month, 6 months and 12 months before and after operation. Results The VAS score of postoperative lumbocrural pain was significantly better than that of the preoperative(P＜0.05). The VAS score of postoperative lumbocrural pain was significantly decreased in 1 month, 6 months and 12 months, and the VAS score of postoperative lumbocrural pain in 12 months was significantly higher than that in 1 month and 6 months(P＜0.05). The postoperative ODI score was significantly higher than the preoperative(P＜0.05). The ODI score in 1 month, 6 months and 12 months was significantly decreased, and the postoperative ODI score in 12 months was significantly higher than that in 1 month and 6 months(P＜0.05). The postJOA score was significantly higher than that preoperative(P＜0.05). The postoperative JOA score was significantly increased in 1 month, 6 months and 12 months, and the postoperative JOA score in 12 months was significantly higher than that in 1 month and 6 months(P＜0.05). The postoperative ROM of surgical observation stage and adjacent segments in 1 month, 6 months, and 12 months was significantly lower than the preoperative(P＜0.05). The intervertebral disc height (DH) of surgical observation stage and adjacent segments in 1 month, 6 months, and 12 months was significantly lower than the preoperative(P＜0.05); there was no significant difference in the adjacent segments between before and after operation(P＞0.05). Conclusion There are few difficulties&trauma and complications in terms of nucleus pulposus extraction combined with interspinous dynamic stabilization & internal fixation system in the treatment of lumbar disc herniation, which can maintain the stability of the disease stage and significantly improve the symptoms of lumbocrural pain in a short time and improve the lumbar perfomance.