Objective To explore the effects of transurethral bipolar plasma kinetics enucleation of prostate on perioperative indexes, international prostate symptom score (IPSS), quality of life (QOL) score and complications in patients with benign prostatic hyperplasia. Methods 132 patients with benign prostatic hyperplasia admitted to our hospital from June 2016 to June 2018 were divided into control group and observation group according to the random number table method, with 66 cases in each group. Control group was treated with transurethral resection of prostate, and observation group was treated with transurethral bipolar plasma kinetics enucleation of prostate. Perioperative indexes (intraoperative blood loss, operative time, urinary catheter indwelling time, hospital stay), IPSS, score and QOL score before operation and at 1 w after operation and the serum biochemical indexes ［serum prostate specific antigen (PSA), estradiol (E-2), testosterone (T), estrogen and androgen ratio E-2/T］were compared between the two groups. And the occurrence of complications was recorded within 3 months after operation. Results The intraoperative blood loss, operative time, urinary catheter indwelling time and hospital stay in observation group were significantly lower than those in control group (all P＜0.05). Compared with before operation, the scores of IPSS and QOL and levels of serum PSA, E2 and E2/T in the two groups at 1 w after operation were significantly decreased while the T level was significantly increased, and the changes in observation group were more obvious than those in control group (all P＜0.05). The incidence rates of erectile dysfunction and electric resection syndrome and total incidence rate of complications within 3 months after operation in observation group were significantly lower than those in control group (all P＜0.05). Conclusion Transurethral bipolar plasma kinetics enucleation of prostate for patients with benign prostatic hyperplasia can significantly improve the clinical symptoms and corresponding indicators, improve patients’ quality of life, and the operation is convenient and safe, and it is an effective clinical treatment method.