【Abstract】 Objective To explore the application and nursing experience of new type thoracic closed drainage tube in conducting thoracic drainage tube fixation. Methods 160 patients with thoracic closed drainage tube after thoracic surgery in our hospital were selected and randomly divided into the control group and the observation group, 80 cases in each group. The control group was given conventional surgical suture fixation and nursing. The observation group was given covered new thoracic closed drainage tube fixation and nursing on the basis of the control group. The drainage tube fixing effect of two groups was comparatively analyzed. Results The drainage time, average daily drainage volume and hospitalization time of patients in the control group were significantly less than those in the control group and the differences were statistically significant (P＜0.05). The interval of replacing adhesive tape and the rate of drainage tube detachment in the observation group were significantly better than those in the control group (P＜0.05). The incidence of unplanned extubation, complications and recurrence rate of the patients in the observation group were significantly lower than those of the control group and the differences were statistically significant (P＜0.05). Conclusion The effect of target nursing during the process of thoracic drainage tube fixation with new type thoracic closed drainage tube is significant, which can reduce the drainage volume, decrease clinical unplanned extubation rate, shorten drainage time, prevent the incidence of complications, and reduce the recurrence rate.