【Abstract】 Objective To observe the expression of apoptosis suppressor gene Livin in nasopharyngeal carcinoma and analyze its correlation with prognosis of nasopharyngeal carcinoma. Methods 28 patients with nasopharyngeal carcinoma and 20 patients with chronic nasopharyngitis were selected from Department of ENT in our hospital and the nasopharyngeal mucosa tissues of these patients were taken as experimental subjects. Immunohistochemical technique SP was used to detect the expression of Livin in two groups. The relationship between the expression level of Livin and pathological features in NPC tissues was also analyzed. At the same time, Cox regression model was used to analyze the prognostic factors. Results The positive expression rate of Livin in nasopharyngeal carcinoma tissues was 6786%, which was higher than 30% of chronic nasopharyngitis tissues (P=0.010). The positive expression rate of Livin in nasopharyngeal carcinoma tissues was significantly different from that in T stage, N stage, clinical stage, cervical lymph node metastasis and distant metastasis（P＜0.05）. The 1 year survival rate of Livin positive patients was 6316%, and the 1 year survival rate of Livin negative expression patients was 100%. We can see that the 1 year survival rate of patients with Livin positive expression is significantly reduced（P=0.035）. And Cox regression model analysis showed that Livin expression, clinical stage, N stage and distant metastasis were independent factors affecting the 1 year survival rate of nasopharyngeal carcinoma patients. Conclusion Apoptosis suppressor gene Livin is highly expressed in nasopharyngeal carcinoma, and its expression is closely related to the prognosis of nasopharyngeal carcinoma patients. It is expected to be a molecular marker to evaluate the prognosis of nasopharyngeal carcinoma.