【Abstract】 Objective To investigate the effects of vitamin A preparation combined with budesonide on immune function of children with bronchial asthma. Methods〓122 children with bronchial asthma treated in our hospital from March 2015 to May 2017 were selected and divided into control group and observation group, according to different treatment methods. All children received the routine treatment, based on this, the control group received the budesonide, while the observation group received the vitamin A preparation combined with budesonide, both tid. for 4 weeks. The immune function, asthma symptoms, serum IL17, IL10, and TGFβ1 levels, clinical efficacy and adverse reactions in the two groups were compared. Results The levels of humoral immunity IgA, IgG and IgM between the two groups had no difference before treatment (P＞0.05), and were increased after treatment. The levels of humoral immunity IgA, IgG and IgM in the observation group were higher than those in the control group after treatment (P＜0.05). The levels of CD3+, CD4+, CD8+, and CD4+/CD8+ in T cell subsets had no difference before treatment (P＞0.05), and above levels except CD4+/CD8+ were increased after treatment. The levels of CD3+, CD4+, CD8+, and CD4+/CD8+ in T cell subsets in the observation group were higher than those in the control group (P＜0.05). The levels of IL17, IL10 and TGFβ1 between the two groups had no difference before treatment (P＞0.05), and the IL17 level was decreased in both groups, the IL10 and TGFβ1 levels were increased on both groups. Both of the decreasing and increasing degrees were more significant in the observation group than in the control group (P＜0.05). The asthma symptoms scores of the two groups were decreased significantly. The asthma symptoms scores in the observation group were lower than those in the control group (P＜0.05). The clinical efficiency of the observation group was significantly higher than that of the control group (P＜0.05). The incidence of adverse reactions was 820% in the control group, which was not significantly different in observation group (P＞0.05). Conclusion The vitamin A preparation combined with budesonide can safely and effectively relieve the symptoms, promote therapeutic effects and improve the immune level of children with bronchial asthma.