【Abstract】 Objective To investigate the correlation of expression levels and radiosensitivity of Flotillin1 and Gab2 proteins in cervical carcinoma. Methods The clinical data of 86 patients with cervical carcinoma treated at our hospital from February 2014 to February 2016 were retrospectively analyzed. The expression of the Flotillin1 and Gab2 proteins in cervical carcinoma was detected by RealtimPCR and compared among cervical carcinoma tissues with different radical chemotherapy sensitivity. Then the correlation of expression levels and radiosensitivity was analyzed by the Pearson correlation. Results The mRNA expression levels of Flotillin1 and Gab2 after radiotherapy were lower than those before chemotherapy (P＜0.05). The expression level of Flotillin1 mRNA and Gab2 mRNA in the tumor disappearance group were lower than those of the tumor disappearance group. The expressions of Flotillin1 mRNA and Gab2 mRNA in tumor healing group were lower than those in tumor recurrence group. The low expression of Flotillin1 mRNA and Gab2 mRNA in tumor disappearance group was positively correlated with tumor disappearance in cervical cancer tissues (r=0.455, P=0.022). The high expression of Flotillin1 mRNA and Gab2 mRNA in uncontrolled tumor group was positively correlated with uncontrolled tumors (r=0.691, P=0.008). The low expression of Flotillin1 mRNA and Gab2 mRNA in tumor healing group was positively correlated with tumor healing (r=0.457, P=0.021). The high expression of Flotillin1 mRNA and Gab2 mRNA in tumor recurrence group was significantly correlated with tumor recurrence (r=0.686, P=0.011). The low expression of Flotillin1 mRNA and Gab2 mRNA in cervical cancer radiotherapysensitive group was positively correlated with chemotherapy sensitivity (r=0.585, P=0.016). The high expression of Flotillin1 mRNA and Gab2 mRNA in the radioresistant group was positively correlated with chemotherapy sensitivity (r=0.498, P=0.019). Conclusion Flotillin1 and Gab2 proteins are highly expressed in cervical cancer tissues, which is related to radiotherapy resistance.