【Abstract】 The morbidity and mortality of cardiovascular diseases increase year by year, and it has become one of the most important diseases threatening human health. Lgr5Wnt/βCatenin signaling pathway has been a hot topic in oncology. The latest research displays that the Wnt signaling pathway is closely related to cardiovascular diseases，as the receptor protein and targetgene of Wnt/βCatenin singeal,Lgr5 is also considered as the potential molecular marker of cardiovascular diseases.we introduced the Lgr5Wnt/βCatenin and overciewed the research progress the relationship between Lgr5Wnt/βCatenin and cardiovasular diseases in recent years.