【Abstract】 Objective To investigate the effects of targetcontrolled infusion of dexmedetomidine on coronary artery bypass grafting. Methods In this study, 94 patients with coronary heart disease undergoing CABG in our hospital from January 2015 to October 2017 were selected and randomly divided into observation group and control group, each group 47 cases. All patients received conventional tracheal intubation general anesthesia. Based on this, the observation cases received the targetcontrolled infusion of dexmedetomidine. The control group cases were infused with the same amount of saline. The levels of diastolic blood pressure (DBP), systolic blood pressure (SBP), MAP, HR and RPP were recorded before induction (T0), after drug injection (T1), before intubation (T2) and 5min after intubation (T3), then the operation time, extubation time and awakening time were also recorded. Results The HR and RPP of the two groups at the T0, T1,T2 had no significant difference (P＞005). The HR at the T3 and T4 in the observation group were significantly lower than those in the control group (P＜005). The DBP, SBP and MAP of the two groups at the T0, T1,T2 had no significant difference (P＞005). The DBP, SBP and MAP at the T3 and T4 in the observation group were significantly lower than those in the control group (P＜005). The operation time of the two groups had no significant difference (P＞005). The extubation time and awakening time of the observation group were significantly shorter than those in the control group (P＜005). Conclusion The application of targetcontrolled infusion of dexmedetomidine on coronary artery bypass grafting in coronary heart disease can reduce the blood pressure and heart rate after intubation, which means that cardiovascular response and myocardial oxygen consumption will be reduced during the intubation.