【Abstract】 Objective The clinical efficacy and side effects of adaptive intensity modulated radiotherapy (ART) and oneway intensity modulated radiotherapy for the treatment of locally advanced cervical cancer were analyzed.Methods From January 2011 to January 2012, 108 patients with locally advanced cervical cancer were selected as the study subjects. The clinical and followup data of all patients were analyzed by retrospective analysis. According to the results of treatment in the data, they were divided into control group and observation group, 50 cases in each group. The control group was given oneway intensity modulated radiotherapy and the patients in the observation group were treated with ART on the basis of routine clinical treatment. Both groups of patients were treated with IMRT or IGRT for external beam irradiation during the treatment period, and cisplatinbased chemotherapy was simultaneously administered. After treatment, the tumor volume was compared between different patients, endangering the characteristics of organ dosimetry. The clinical curative effect and longterm survival of the control group and observation group were compared. The occurrence of side effects was recorded. Results The volume of GTV, the volume of pCTV and the volume of small intestine in observation group were significantly reduced after 15 times of external exposure (P＜005). The urinary bladder Dmean, Dmax, D 01cc, Dlcc, rectal Dmean, Dmax, D 01cc, Dlcc, small intestine Dmean, Dmax, V30, V45 and V50 were all lower than the first. The difference between the rest of the small intestine and the first goal was statistically significant (P＜005). There was no significant difference between the control group and the observation group in the parameters of OARs DVH and the total clinical efficiency (9200% vs 9655%) (P＞ 005). There was no significant difference between the control group and the observation group in the OS and PFS after 5 years of followup (8800% vs 9138% and 8000% vs 8793%, respectively) (P＞ 005). The incidence of acute diarrhea in the observation group was significantly lower than that in the control group, with statistically significant differences (P＜005). There was no difference between the two groups in the incidence of chronic toxic and side effects such as hematuria, pollakiuria, hydronephrosis, urinary incontinence, radiation cystitis, radiation proctitis, diarrhea, fecal incontinence and colorectal hemorrhage. 005)，the difference was not statistically significant (P＞ 005).Conclusion ART and oneway intensity modulated radiotherapy in the treatment of locally advanced cervical cancer patients have significant clinical efficacy, but ART treatment can significantly reduce the incidence of acute diarrhea in patients with adverse reactions, with better safety.