【Abstract】 Objective To explore the effects of angiotensinII on NLRP3 inflammation in H9C2 cells.Methods All experiments were performed by using of the H9C2 cells, which were cultured in vitro and treated with 106mol/l of AngⅡ. The cells were collected at varying time point.Expression levels of NLRP3, ASC, Caspase1, IL1β mRNA were detected with quantitative realtime PCR, expression levels of NLRP3, ASC, Caspase1, IL1β protein were detected by western blot, and the content of inflammatory factors in supernatant detected through ELISA.Results The expression of mRNA levels of NLRP3, ASC, Caspase1 and IL1β were significantly higher than that with 0h group (P＜005). The expression of protein levels of NLRP3, ASC, Caspase1 and IL1β were significantly higher than those in 0h group(P＜005). The content of inflammatory factors IL1β in the supernatant were significantly higher than those in the 0h group (P＜005).Conclusion Treatment on H9C2 cells with AngⅡ could give rise to the mRNA and protein expression levels of NLRP3, ASC, Caspase1 and IL1β，and increase the content of IL1β in the supernatant. AngiotensinII could induce inflammation of cardiomyocytes by activating NLRP3 inflammatory bodies, and this process is associated with angiotensinII leading to cardiomyopathy.