Abstract:【Abstract】 After comparative interpretation of essentials and highlights of 2012 Kidney Disease Improving Global Outcomes (KDIGO) guideline and those of Acute Disease Quality Initiative (ADQI) consensus guideline, we summarized the key points and improvements in four aspects in continuous renal replacement therapy including patient selection and timing, precision continuous renal replacement therapy and solute control, precision fluid management and role of technology for the management of AKI in critically ill patients. This paper will provide references for CRRT in clinical practice.