Abstract:【Abstract】 Objective To discuss the clinical efficacy of stilamin combined with Xuebijing in the treatment of severe acute pancreatitis and its effect on serum IL10, IL18 and TNFα. Methods 80 patients with severe acute pancreatitis admitted to our hospital from September 2016 to February 2017 were selected as the subjects. According to the different treatment methods, the patients were divided into experimental group and control group. The patients in the experimental group were treated with stilamin on the basis of routine treatment. The experimental group was treated with Xuebijing treatment on the basis of the control group. The clinical symptoms to reduce and recovery time, blood test results, especially serum amylase index recovery of the two groups of patients in the treatment were observed. The serum IL10, IL18 and TNFα were compared between the two groups. Results Before treatment, the serum amylase, blood urea nitrogen, blood glucose, white blood cell count, IL10, IL18 and TNFα were not statistically significantly different after treatment. The total effective rate of the experimental group (9750%) was higher than that of the control group (8000%) (P<005). The serum amylase, blood urea nitrogen, blood calcium ,blood glucose, white blood cell count leukocyte count in experimental group were higher than control group (P<005). The serum IL10 was significantly increased. IL18 and TNFα were significantly decreased. The IL10, IL18 and TNFα in the experimental group was higher than that of the control group (P<005). Conclusion Stilamin combined with Xuebijing treatment can improve the efficacy of severe acute pancreatitis, restore serum IL10 levels and reduce serum IL18, TNFα levels.