Abstract:【Abstract】 Objective To investigate the diagnostic value of NTproBNP and GDF15 in patients with simple aortic valve insufficiency. Methods 138 AR patients with heart failure and 32 normal controls from March 2014 to December 2016 in our hospital were enrolled in this study. The diagnostic value of GDF15 with Enzymelinked immunosorbent assay (ELISA) was evaluated. Results NTproBNP and GDF15 levels were significantly increased in ARtreated group (P<005) compared with those in normal control group. There was no significant difference between gradeⅠand Ⅱin heart failure (P>005). There was significant difference between grade Ⅲ andⅠ, Ⅱin heart failure (P<005). NTproBNP combined with GDF15 levels in the diagnosis of AR alone heart failure, the combination of the two had a high clinical value for the diagnosis of AR severe heart failure. Conclusion The detection of NTproBNP and GDF15 levels combined with cardiac function and other data is conducive to the screening of patients with severe failure, which has important guiding significance for clinical diagnosis and treatment.