【Abstract】 Objective To research the clinical efficacy of abdominal aortic balloon blockage combined with uterine artery embolization in the treatment of pernicious placenta previa . Methods 69 pernicious placenta previa patients between April 2012 and November 2015 of our hospital were selected. All of them were taken Cesarean section operation, and divided them into control group and research group by different intervention methods. The control group was treated by uterine artery embolization, while the research group was treated by abdominal aortic balloon blockage combined with uterine artery embolization. The condition of placental implantation, intraoperative transfusion, bleeding volume, operation duration, long of stay, hysterectomy rate, Apgar score of 1 minute and 5 minutes after birth, newborn birth weight and complications of two groups were observed. Results The condition of placental implantation, such as types of penetrates the posterior wall of the bladder, implant the posterior wall of the bladder, penetrating the muscular layer, partial myolayer implantation of two groups had no statistical difference (P＞005). The intraoperative transfusion, bleeding volume and operation duration of research group were much lower than that of control group（P＜005）. The long of stay and the hysterectomy rate of research group were much lower than that of control group（P＜005）. The Apgar 1min score of research group and the hysterectomy rate were 843±091 and 883±094 (P＞005). The Apgar 5min score of research group and control group were 958±064 and 964±061 (P＞005). The newborn birth weight of research group and control group were 263±024 and 274±028 kg (P＞005). Conclusion Abdominal aortic balloon blockage combined with uterine artery embolization has low hysterectomy rate, can reduced blood transfusion and bleeding volume, shorten operation duration and hospital stay, and improve clinical outcomes.