【Abstract】 Objective To investigate the effect of longchain noncoding DRAIC on the migration and invasion of gastric cancer cells and its mechanism. Methods qPCR was used to detect the expression and difference of DRAIC in gastric carcinoma and cell lines. Double luciferase reporter gene was used to detect the interaction between DRAIC and miR223. The effect of DRAIC on cell cycle and apoptosis of gastric cancer cells was detected by flow cytometry. Transwell invasion assay was used to detect the changes of invasion behavior of gastric cancer cells after DRAIC. Scrap healing test was used to detect the changes of migration behavior of gastric cancer cells after DRAIC. Results Compared with normal stomach tissue, the expression level of DRAIC was upregulated in gastric cancer tissues. The expression level of DRAIC in SGC7901 cell line was the highest. The difference was statistically significant. Double luciferase assay confirmed that DRAIC could bind to the 3 'UTR of miR223 and could regulate the expression and activity of miR223. Inhibition of DRAIC expression can promote apoptosis of gastric cancer cells. Inhibition of DRAIC expression can inhibit gastric cancer cell migration and invasion. Conclusion DRAIC can regulate the expression of miR223 and affect the migration and invasion of gastric cancer cells.