Abstract:【Abstract】 With the increase of the incidence in diabetes and the prolongation of the course in disease, diabetic cardiomyopathy has become one of the main causes of death in Diabetic. However, the pathogenesis of DCM has not yet been fully elucidated.To establish an ideal DCM animal model can further study the pathogenesis and intervention measures of DCM.We summarizes and discusses the research progress of the experimental animal model of DCM in this paper.We discuss pathogenesis, manifestations,pathological changes of the heart and its application status in detail by 3 kinds of animal models which are the induced, spontaneous and transgenic animal models.We debate their advantages and disadvantages in order to provide a reference for the study of DCM pathogenesis and related drug development.