【Abstract】 Objective To research enhanced blood glucose treating Ischemic stroke stress hyperglycemia.Methods We collect the material of ischemic stroke stress hyperglycemia patients whose glucose＞10mmol/l. The patients were divided into two groups depending on the glucose. We controled the glucose by insulin pump. The strengthening hypoglycemic group’random blood glucose was below 78mmol/l.The ordinary hypoglycemic group’ random blood glucose was below 10mol/l. We checked CRP, TNFa on admission, 3d, 7d and 2w after admission. The incidence of hypoglycemia, infarct hemorrhage, pulmonary infection and deep vein thrombosis were observed. The nerve function was measured with modified Rankin scale and the ability of life was observed by Barthel index.Results CRP and TNFa expressions elevated first and decresed later, which had no significantly deference between the two group (P＞005). The incidence of hypoglycemia, infarct hemorrhage, pulmonary infection, deep vein thrombosis haf no deference between the two groups (P＞005). Rankin and Barthel index 3 months after admission between the two groups had no deference(P＞005).Conclusion Enhanced blood glucose treating ischemic stroke stress hyperglycemia can’t reduce the inflammatory response, can’t improve the Rankin and Barthel index and the incidence of complications.